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Dansyl-NECA

Cat. No. 5122 Submit a Review Datasheet / COA / SDS

Discontinued Product

5122 has been discontinued.

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Description: Potent and selective fluorescent adenosine A1 agonist
Chemical Name: 1-Deoxy-1-[6-[[6-[[[5-dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for Dansyl-NECA

Dansyl-NECA is a high affinity and selective fluorescent adenosine A1 receptor agonist (Ki values are 27, 3600 and 4300 nM for A1, A3 and A2 receptors, respectively). Permits visualization of A1 receptors in the rat cerebellar cortex.

Technical Data for Dansyl-NECA

M. Wt 640.75
Formula C30H40N8O6S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 219982-12-4
PubChem ID 10009321
InChI Key CJDPJPUVKHWZHU-YRIIQKNPSA-N
Smiles CN(C)C1=C2C(C(S(NCCCCCCNC3=NC=NC4=C3N=CN4[C@H]5[C@H](O)[C@H](O)[C@@H]([C@@](NCC)=O)O5)(=O)=O)=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Dansyl-NECA

References are publications that support the biological activity of the product.

Macchia et al (1998) Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. Bioorg. Med. Chem. Lett. 8 3223 PMID: 9873707

Kozma et al (2013) Fluorescent ligands for adenosine receptors. Bioorg. Med. Chem. Lett. 23 26 PMID: 23200243

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Citations for Dansyl-NECA

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Currently there are no citations for Dansyl-NECA.

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Literature in this Area

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
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Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.