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GKA 50

Cat. No. 5133 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Glucokinase activator
Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for GKA 50

GKA 50 is a potent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.

Compound Libraries for GKA 50

GKA 50 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GKA 50

M. Wt 464.51
Formula C26H28N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 851884-87-2
PubChem ID 11340230
InChI Key OCBMECSFDVUYQN-ROUUACIJSA-N
Smiles O=C(NC3=NC=C(C(O)=O)C=C3)C1=CC(O[C@@H](C)COC)=CC(O[C@@H](C)CC2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GKA 50

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.45 100

Preparing Stock Solutions for GKA 50

The following data is based on the product molecular weight 464.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for GKA 50

References are publications that support the biological activity of the product.

Coope et al (2006) Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br.J.Pharmacol. 149 328 PMID: 16921397

Johnson et al (2007) Glucokinase activators: molecular tools for studying the physiology of Ins-Secr.g cells. Biochem.Soc.Trans. 35 1208 PMID: 17956314

If you know of a relevant reference for GKA 50, please let us know.

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Citations for GKA 50

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