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Description: Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Purity: ≥99% (HPLC)
Biological Activity for TCID
TCID is a selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.
Technical Data for TCID
| M. Wt | 283.92 |
| Formula | C9H2Cl4O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 30675-13-9 |
| PubChem ID | 2729042 |
| InChI Key | IDLAOWFFKWRNHB-UHFFFAOYSA-N |
| Smiles | O=C(CC2=O)C1=C2C(Cl)=C(Cl)C(Cl)=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCID
References for TCID
References are publications that support the biological activity of the product.
Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054
de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863 PMID: 23484054
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Keywords: TCID, TCID supplier, selective, ubiquitin, c-terminal, hydrolase-L3, UCH-L3, UCHL3, inhibitors, inhibits, deubiquitinating, enzymes, DUBs, ubiquitination, Deubiquitinating, Enzymes, 5179, Tocris Bioscience
Citations for TCID
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Currently there are no citations for TCID.
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