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(S)-(-)-Bay K 8644

Cat. No. 1546 5 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644
Chemical Name: (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (S)-(-)-Bay K 8644

(S)-(-)-Bay K 8644 is a L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.

Racemate and (R)-(+)-Enantiomer also available.

Compound Libraries for (S)-(-)-Bay K 8644

(S)-(-)-Bay K 8644 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (S)-(-)-Bay K 8644

M. Wt 356.3
Formula C16H15F3N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 98625-26-4
PubChem ID 6603728
InChI Key ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
Smiles O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@H]1[C@]2=CC=CC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (S)-(-)-Bay K 8644

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.63 100
ethanol 35.63 100

Preparing Stock Solutions for (S)-(-)-Bay K 8644

The following data is based on the product molecular weight 356.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for (S)-(-)-Bay K 8644

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for (S)-(-)-Bay K 8644

References are publications that support the biological activity of the product.

Franckowiak et al (1985) The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 114 223 PMID: 2412855

O'Neill and Bolger (1988) Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 21 865 PMID: 2465070

Ravens and Schopper (1990) Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 341 232 PMID: 1692975

If you know of a relevant reference for (S)-(-)-Bay K 8644, please let us know.

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Keywords: (S)-(-)-Bay K 8644, (S)-(-)-Bay K 8644 supplier, Ca2+-channel, activators, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Ca2+, (S)-(-)-BayK8644, Cav1.x, 1546, Tocris Bioscience

5 Citations for (S)-(-)-Bay K 8644

Citations are publications that use Tocris products. Selected citations for (S)-(-)-Bay K 8644 include:

Burtscher et al (2014) Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. Biochim Biophys Acta 1838 2053 PMID: 24796500

Landstrom et al (2011) Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Eneuro 4 214 PMID: 21216834

Wei et al (2017) Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions. Sci Rep 7 981 PMID: 28428622

Chen et al (2011) Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors. Nat Neurosci 14 570 PMID: 21441923

Do you know of a great paper that uses (S)-(-)-Bay K 8644 from Tocris? Please let us know.

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