Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOXA 06 dihydrochloride
Description: Potent ROCK inhibitor
Chemical Name: 2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for OXA 06 dihydrochloride
OXA 06 dihydrochloride is a potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.
Technical Data for OXA 06 dihydrochloride
| M. Wt | 404.31 |
| Formula | C21H18FN3.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1825455-91-1 |
| PubChem ID | 91691120 |
| InChI Key | ZRBCUSMZOWMVJS-UHFFFAOYSA-N |
| Smiles | FC1=CC=CC=C1CNCC(C=C4)=CC=C4C2=C3C(NC=C3)=NC=C2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OXA 06 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.43 | 100 |
Preparing Stock Solutions for OXA 06 dihydrochloride
The following data is based on the product molecular weight 404.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.37 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for OXA 06 dihydrochloride
References for OXA 06 dihydrochloride
References are publications that support the biological activity of the product.
Vigil et al (2012) ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 72 5338 PMID: 22942252
If you know of a relevant reference for OXA 06 dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: OXA 06 dihydrochloride, OXA 06 dihydrochloride supplier, OXA06, dihydrochloride, rho, kinases, ROCK, potent, inhibitors, inhibits, 944955_32_2, Rho-kinases, 5182, Tocris Bioscience
Citations for OXA 06 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for OXA 06 dihydrochloride. Do you know of a great paper that uses OXA 06 dihydrochloride from Tocris? Please let us know.
Reviews for OXA 06 dihydrochloride
There are currently no reviews for this product. Be the first to review OXA 06 dihydrochloride and earn rewards!
Have you used OXA 06 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.