Home / Pharmacology / GPCRs / 7-TM Receptors / Orphan 7-TM Receptors / Orphan 7-TM Receptor Antagonists / NIBR 189

NIBR 189

Cat. No. 5203 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective EBI2 (GPR183) receptor antagonist
Chemical Name: (2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NIBR 189

NIBR 189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

Technical Data for NIBR 189

M. Wt 429.31
Formula C21H21BrN2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1599432-08-2
PubChem ID 36295259
InChI Key OFHXXBRBGWUOHR-NYYWCZLTSA-N
Smiles BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NIBR 189

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.93 100

Preparing Stock Solutions for NIBR 189

The following data is based on the product molecular weight 429.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.65 mL 23.29 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for NIBR 189

References are publications that support the biological activity of the product.

Gessier et al (2014) Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J.Med.Chem. 57 3358 PMID: 24678947

If you know of a relevant reference for NIBR 189, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Orphan 7-TM Receptor Antagonists

Keywords: NIBR 189, NIBR 189 supplier, NIBR189, potent, selective, EBI2, GPR183, Epstein-bar, virus, induced, gene, 2, receptors, antagonists, orally, bioavailable, Orphan, 7-TM, Receptors, 5203, Tocris Bioscience

Citations for NIBR 189

Citations are publications that use Tocris products.

Currently there are no citations for NIBR 189. Do you know of a great paper that uses NIBR 189 from Tocris? Please let us know.

Reviews for NIBR 189

There are currently no reviews for this product. Be the first to review NIBR 189 and earn rewards!

Have you used NIBR 189?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review