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Submit ReviewXAP 044
Description: Potent and selective mGlu7 antagonist
Chemical Name: 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Biological Activity for XAP 044
XAP 044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.
Technical Data for XAP 044
| M. Wt | 380.13 |
| Formula | C15H9IO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 196928-50-4 |
| PubChem ID | 5428913 |
| InChI Key | XXZKJJYWINSUMJ-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(C(C(OC3=CC=C(I)C=C3)=CO2)=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for XAP 044
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.01 | 100 | |
| ethanol | 7.6 | 20 |
Preparing Stock Solutions for XAP 044
The following data is based on the product molecular weight 380.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.15 mL | 26.31 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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Product Datasheets for XAP 044
References for XAP 044
References are publications that support the biological activity of the product.
Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975 PMID: 24596089
If you know of a relevant reference for XAP 044, please let us know.
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Keywords: XAP 044, XAP 044 supplier, XAP044, potent, specific, mGlu7, antagonists, glutamate, metabotropic, group, III, receptors, venus, flytrap, domain, VFTD, anti-anxiety, Brain, penetrant, Glutamate, (Metabotropic), Group, Receptors, 5248, Tocris Bioscience
Citations for XAP 044
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Reviews for XAP 044
Average Rating: 4 (Based on 1 Review.)
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XAP044 successfully antagonize the effect of L-AP4- stimulated mGlu7 receptors.
By
Anonymous on 01/05/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK293 cells
We have studied the cross-talk between mGlu7 and alpha1-adrenergic receptor in recombinant HEK293 cells and XAP 044 was successfully used to antagonize the effect of L-AP4. Briefly, after transfection, we measured the modulation of L-AP4, the mGlu7 receptor agonist on phenylephrine-induced stimulation of inositol phosphates formation. The effect of L-AP4 was antagonised by XAP044 (at 10 and 100 micromolar)
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