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Submit ReviewSCH 51344
Description: Potent MTH1 inhibitor
Chemical Name: 2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
Purity: ≥99% (HPLC)
Biological Activity for SCH 51344
SCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.
Technical Data for SCH 51344
| M. Wt | 316.35 |
| Formula | C16H20N4O3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 171927-40-5 |
| PubChem ID | 9995890 |
| InChI Key | YWEGXZZAORIRQR-UHFFFAOYSA-N |
| Smiles | CC1=NN=C(N3)C1=C(NCCOCCO)C2=C3C=CC(OC)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SCH 51344
References for SCH 51344
References are publications that support the biological activity of the product.
Walsh et al (1997) SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene 15 2553 PMID: 9399643
Kumar et al (1999) SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway. Ann.N.Y.Acad.Sci. 886 122 PMID: 10667210
Huber et al (2014) Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508 222 PMID: 24695225
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Keywords: SCH 51344, SCH 51344 supplier, SCH51344, potent, MTH1, inhibitors, inhibits, ras, transformation, anticancer, hydrolases, g, proteins, mutT, homologue, NUDT1, MutT, homolog-1, (MTH1), 5280, Tocris Bioscience
1 Citation for SCH 51344
Citations are publications that use Tocris products. Selected citations for SCH 51344 include:
Andrzej et al (2022) 1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research. Molecules 27 PMID: 35566124
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