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Submit ReviewLY 315920
Description: Selective secreted phospholipase A2 (sPLA2) inhibitor
Alternative Names: Varespladib
Chemical Name: 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic aci
Purity: ≥98% (HPLC)
Biological Activity for LY 315920
Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Has no effect on cytosolic PLA2 or COX-1 and COX-2 activity. Attenuates sPLA2-induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA2-induced contractions of lung pleural strips ex vivo. Orally available.
Technical Data for LY 315920
| M. Wt | 380.39 |
| Formula | C21H20N2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 172732-68-2 |
| PubChem ID | 155815 |
| InChI Key | BHLXTPHDSZUFHR-UHFFFAOYSA-N |
| Smiles | OC(COC1=C2C(N(CC3=CC=CC=C3)C(CC)=C2C(C(N)=O)=O)=CC=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LY 315920
References for LY 315920
References are publications that support the biological activity of the product.
Snyder et al (1999) Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J.Pharmacol.Exp.Ther. 288 1117 PMID: 10027849
Oslund et al (2008) Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J.Med.Chem. 51 4708 PMID: 18605714
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Keywords: LY 315920, LY 315920 supplier, LY315920, selective, secreted, phospholipase, A2, sPLA2, inhibitors, inhibits, orally, available, Varespladib, Phospholipases, 5313, Tocris Bioscience
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