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Description: Negative allosteric modulator of CB1 receptors
Chemical Name: N-(4-Chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]urea
Purity: ≥99% (HPLC)
Biological Activity for PSNCBAM-1
PSNCBAM-1 is a CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats.
Compound Libraries for PSNCBAM-1
PSNCBAM-1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PSNCBAM-1
| M. Wt | 392.88 |
| Formula | C22H21ClN4O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 877202-74-9 |
| PubChem ID | 11560249 |
| InChI Key | HDAYFSFWIPRJSO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(NC2=CC(C3=CC=CC(N4CCCC4)=N3)=CC=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSNCBAM-1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.29 | 100 |
Preparing Stock Solutions for PSNCBAM-1
The following data is based on the product molecular weight 392.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.73 mL | 25.45 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets for PSNCBAM-1
References for PSNCBAM-1
References are publications that support the biological activity of the product.
Horswill et al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805 PMID: 17592509
German et al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758 PMID: 25162172
If you know of a relevant reference for PSNCBAM-1, please let us know.
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Keywords: PSNCBAM-1, PSNCBAM-1 supplier, subtype, selective, cb1, cannabinoids, receptors, negative, allosteric, modulators, antagonists, hypophagic, NAM, CB1, Receptors, 5321, Tocris Bioscience
Citations for PSNCBAM-1
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Currently there are no citations for PSNCBAM-1. Do you know of a great paper that uses PSNCBAM-1 from Tocris? Please let us know.
Reviews for PSNCBAM-1
Average Rating: 5 (Based on 1 Review.)
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Works as described, another very interesting compound..
By
Jonathan Fay on 05/30/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: COSH-1
Allosteric enhancement of radiolabeled agonist binding.
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