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Submit ReviewGap19
Description: Cx43 hemichannel blocker
Purity: ≥95% (HPLC)
Biological Activity for Gap19
Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.
Technical Data for Gap19
| M. Wt | 1161.45 |
| Formula | C55H96N14O13 |
| Sequence | KQIEIKKFK |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1507930-57-5 |
| PubChem ID | 91691126 |
| InChI Key | IEAKEKFIXUZWEH-PKMKMBMKSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Gap19
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for Gap19
References for Gap19
References are publications that support the biological activity of the product.
Boengler et al (2013) Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 4 PMID: 23760924
Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389
Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 8 PMID: 25374505
If you know of a relevant reference for Gap19, please let us know.
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Keywords: Gap19, Gap19 supplier, Selective, Cx43, hemichannels, blockers, blocks, Connexin43, Panx-1, gap, junctions, Gap, Channels, 5353, Tocris Bioscience
5 Citations for Gap19
Citations are publications that use Tocris products. Selected citations for Gap19 include:
Best et al (2019) Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. Nat Commun 10 4190 PMID: 31519898
Juan V et al (2021) Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity? Front Pharmacol 12 613449 PMID: 33867979
Almad et al (2016) Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia 64 1154 PMID: 27083773
Chen et al (2018) Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway. Front Cell Neurosci 12 372 PMID: 30386214
Miyuki et al (2023) The Involvement of Cx43 in JNK1/2-Mediated Endothelial Mechanotransduction and Human Plaque Progression. Int J Mol Sci 24 PMID: 36674690
Do you know of a great paper that uses Gap19 from Tocris? Please let us know.
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