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Submit ReviewGSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.
GSK LSD 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
M. Wt | 289.24 |
Formula | C14H20N2.2HCl |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 2102933-95-7 |
PubChem ID | 91663353 |
InChI Key | PJFZOGMSPBHPNS-WICJZZOFSA-N |
Smiles | C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 28.92 | 100 | |
DMSO | 28.92 | 100 |
The following data is based on the product molecular weight 289.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.46 mL | 17.29 mL | 34.57 mL |
5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
References are publications that support the biological activity of the product.
If you know of a relevant reference for GSK LSD 1 dihydrochloride, please let us know.
Keywords: GSK LSD 1 dihydrochloride, GSK LSD 1 dihydrochloride supplier, GSKLSD1, dihydrochloride, potent, selective, lysine, specific, demethylases, LSD1, inhibitors, inhibits, SGC, structural, genomics, consortium, histone, Histone, Demethylases, 5361, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for GSK LSD 1 dihydrochloride include:
Ping et al (2022) Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models. Mol Psychiatry 27 3355-3366 PMID: 35296809
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.