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Description: BiP (Hsp70-5) ER chaperone inducer
Chemical Name: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid
Purity: ≥98% (HPLC)
Biological Activity for BIX
BIX is a BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
Technical Data for BIX
| M. Wt | 209.22 |
| Formula | C9H7NO3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 101714-41-4 |
| PubChem ID | 16656807 |
| InChI Key | SVFLBLCWKKQKDW-UHFFFAOYSA-N |
| Smiles | O=C(CSC#N)C1=CC=C(O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BIX
References for BIX
References are publications that support the biological activity of the product.
Inokuchi et al (2009) Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 50 334 PMID: 18757512
Oida et al (2008) Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 1208 217 PMID: 18395193
Kudo et al (2008) A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15 364 PMID: 18049481
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Keywords: BIX, BIX supplier, BIP, ER, endoplasmic, reticulum, chaperones, inducers, stress, binding, immunoglobulin, protein, Hsp70, Other, stress/UPR, 5375, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
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