Home / Cell Biology / Cell Metabolism / Lipid Metabolism / Other Lipid Metabolism / Other Lipid Metabolism Inhibitors / Ro 48-8071 fumarate

Ro 48-8071 fumarate

Cat. No. 5389 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: 2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ro 48-8071 fumarate

Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).

Compound Libraries for Ro 48-8071 fumarate

Ro 48-8071 fumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Ro 48-8071 fumarate

M. Wt 564.44
Formula C23H27BrFNO2.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 189197-69-1
PubChem ID 9959583
InChI Key XCYAYLWZCRGKDS-WLHGVMLRSA-N
Smiles FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 48-8071 fumarate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.29 20 with gentle warming
DMSO 56.44 100

Preparing Stock Solutions for Ro 48-8071 fumarate

The following data is based on the product molecular weight 564.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.86 mL 17.72 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Ro 48-8071 fumarate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Ro 48-8071 fumarate

References are publications that support the biological activity of the product.

Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to SimV.. J.Lipid.Res. 38 373 PMID: 9162756

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795 PMID: 21315634

Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265 PMID: 23441171

If you know of a relevant reference for Ro 48-8071 fumarate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Lipid Metabolism Inhibitors

Keywords: Ro 48-8071 fumarate, Ro 48-8071 fumarate supplier, Ro48-8071, fumarate, 2,3-Oxidosqualene, OSC, inhibitors, inhibits, cholesterol, synthesis, Ebola, virus, EBOV, Other, Isomerases, Lipid, Metabolism, Antivirals, 5389, Tocris Bioscience

Citations for Ro 48-8071 fumarate

Citations are publications that use Tocris products.

Currently there are no citations for Ro 48-8071 fumarate. Do you know of a great paper that uses Ro 48-8071 fumarate from Tocris? Please let us know.

Reviews for Ro 48-8071 fumarate

There are currently no reviews for this product. Be the first to review Ro 48-8071 fumarate and earn rewards!

Have you used Ro 48-8071 fumarate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review