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TC AQP1 1

Cat. No. 5412 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Aquaporin 1 (AQP1) channel blocker
Chemical Name: 3,3'-(1,3-Phenylene)bis(2-propenoic acid)
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC AQP1 1

TC AQP1 1 is an aquaporin 1 (AQP1) channel blocker (IC50 = 8 μM). Inhibits water flux in Xenopus oocytes.

Technical Data for TC AQP1 1

M. Wt 218.211
Formula C12H10O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 37710-81-9
PubChem ID 794091
InChI Key KRXUBZPHAPGHPE-YDFGWWAZSA-N
Smiles O=C(O)/C=C/C1=CC(/C=C/C(O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC AQP1 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.82 100

Preparing Stock Solutions for TC AQP1 1

The following data is based on the product molecular weight 218.211. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.83 mL
5 mM 0.92 mL 4.58 mL 9.17 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for TC AQP1 1

References are publications that support the biological activity of the product.

Seeliger et al (2013) Discovery of novel human aquaporin-1 blockers. ACS Chem.Biol. 8 249 PMID: 23113556

If you know of a relevant reference for TC AQP1 1, please let us know.

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Keywords: TC AQP1 1, TC AQP1 1 supplier, TCAQP11, aquaporin1, channels, blockers, AQP1, Aquaporins, 5412, Tocris Bioscience

1 Citation for TC AQP1 1

Citations are publications that use Tocris products. Selected citations for TC AQP1 1 include:

Angamuthu et al (2020) Genomic and Transcriptomic Analysis for Identification of Genes and Interlinked Pathways Mediating Artemisinin Resistance in Leishmania donovani. Genes (Basel) 11 PMID: 33213096

Do you know of a great paper that uses TC AQP1 1 from Tocris? Please let us know.

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