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BTC

Cat. No. 5421 Submit a Review Datasheet / COA / SDS

Discontinued Product

5421 has been discontinued.

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Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for BTC

Selective estrogen receptor modulator (SERM); induces regression of tamoxifen-resistant, hormone independent xenograft tumors. Displays no significant gain in uterine weight in treated mice.

Technical Data for BTC

M. Wt 242.29
Formula C14H10O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 63676-22-2
PubChem ID 445920
InChI Key MDGWZLQPNOETLH-UHFFFAOYSA-N
Smiles OC(C=C3)=CC=C3C2=CC1=CC=C(O)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BTC

References are publications that support the biological activity of the product.

Molloy et al (2014) Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol.Cancer.Ther. 13 2515 PMID: 25205655

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Pathways for BTC

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.