Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCIM 0216
Description: Selective TRPM3 agonist
Chemical Name: 3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide
Purity: ≥98% (HPLC)
Biological Activity for CIM 0216
CIM 0216 is a selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.
Compound Libraries for CIM 0216
CIM 0216 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CIM 0216
| M. Wt | 347.41 |
| Formula | C21H21N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1031496-06-6 |
| PubChem ID | 42887770 |
| InChI Key | KSEXDSJYVSEVGF-UHFFFAOYSA-N |
| Smiles | O=C(NC1=NOC(C)=C1)C(C2=CC=CC=C2)N(CCC3)C4=C3C=CC=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CIM 0216
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.74 | 100 |
Preparing Stock Solutions for CIM 0216
The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for CIM 0216
References for CIM 0216
References are publications that support the biological activity of the product.
Held et al (2015) Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc.Natl.Acad.Sci.U.S.A. 112 E1363 PMID: 25733887
If you know of a relevant reference for CIM 0216, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CIM 0216, CIM 0216 supplier, CIM0216, TRPM3, transient, potential, membrane, ion, channels, pain, insulin, TRPM, 5521, Tocris Bioscience
2 Citations for CIM 0216
Citations are publications that use Tocris products. Selected citations for CIM 0216 include:
Rubil and Thiel (2017) Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels (Austin) 11 79 PMID: 27356187
Xi et al (2021) ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Nat Commun 12 1401 PMID: 33658516
Do you know of a great paper that uses CIM 0216 from Tocris? Please let us know.
Reviews for CIM 0216
There are currently no reviews for this product. Be the first to review CIM 0216 and earn rewards!
Have you used CIM 0216?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image