Napabucasin

Cat. No. 5522 Submit a Review Datasheet / COA / SDS

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Description: STAT3 inhibitor; also blocks cancer stem cell self-renewal

Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Napabucasin

Napabucasin is a STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

Compound Libraries for Napabucasin

Napabucasin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Napabucasin

M. Wt	240.21
Formula	C₁₄H₈O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	83280-65-3
PubChem ID	10331844
InChI Key	DPHUWDIXHNQOSY-UHFFFAOYSA-N
Smiles	O=C(C1=C2C=C(C(C)=O)O1)C3=CC=CC=C3C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Napabucasin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.8	20

Preparing Stock Solutions for Napabucasin

The following data is based on the product molecular weight 240.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	20.82 mL	104.08 mL	208.15 mL
1 mM	4.16 mL	20.82 mL	41.63 mL
2 mM	2.08 mL	10.41 mL	20.82 mL
10 mM	0.42 mL	2.08 mL	4.16 mL

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Product Datasheets for Napabucasin

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Napabucasin

References are publications that support the biological activity of the product.

Li et al (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 112 1839 PMID: 25605917

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Citations for Napabucasin

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Pathways for Napabucasin

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.