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Description: GABA uptake inhibitor
Chemical Name: 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for (S)-SNAP 5114
(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.
Technical Data for (S)-SNAP 5114
| M. Wt | 505.61 |
| Formula | C30H35NO6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 157604-55-2 |
| PubChem ID | 10458835 |
| InChI Key | VDLDUZLDZBVOAS-QFIPXVFZSA-N |
| Smiles | O=[C@]([C@@H]1CN(CCOC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C2=CC=C(OC)C=C2)CCC1)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (S)-SNAP 5114
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 25.28 | 50 | |
| DMSO | 50.56 | 100 |
Preparing Stock Solutions for (S)-SNAP 5114
The following data is based on the product molecular weight 505.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.89 mL | 19.78 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for (S)-SNAP 5114
References for (S)-SNAP 5114
References are publications that support the biological activity of the product.
Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207 PMID: 7874447
Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335 PMID: 8939442
Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399 PMID: 10974324
If you know of a relevant reference for (S)-SNAP 5114, please let us know.
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Keywords: (S)-SNAP 5114, (S)-SNAP 5114 supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-2, GAT-3, Transporters, Monoamine, Neurotransmitter, (S)-SNAP5114, 1561, Tocris Bioscience
5 Citations for (S)-SNAP 5114
Citations are publications that use Tocris products. Selected citations for (S)-SNAP 5114 include:
Herd et al (2013) Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. J Neurosci 33 14850 PMID: 24027285
Kinney (2005) GAT-3 transporters regulate inhibition in the neocortex. Mol Pain 94 4533 PMID: 16135550
Kékesi et al (2015) Recurrent seizure-like events are associated with coupled astroglial synchronization. J Neurosci 9 215 PMID: 26150770
Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Physiol 36 607 PMID: 26758848
Kersanté et al (2013) A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Neurophysiol 591 2429 PMID: 23381899
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Reviews for (S)-SNAP 5114
Average Rating: 5 (Based on 1 Review.)
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Modulation of action potentials.
By
Sergiy Sylantyev on 12/15/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Hippocampus
(S)-SNAP 5114 was used to block a GAT-3 GABA transporter in hippocampal neural tissue. Application of (S)-SNAP 5114 decreased significantly the spiking probability in hippocampal neurons and coincidence detection time window for excitatory inputs (see illustration). 20 min. washout restored the spiking probability to ~70-80% of control value.
Preparation of 10 mM stock requires sonication.
Literature in this Area
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