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Submit ReviewTAT-cyclo-CLLFVY
Description: Selective HIF-1 dimerization inhibitor
Purity: ≥95% (HPLC)
Biological Activity for TAT-cyclo-CLLFVY
TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
Technical Data for TAT-cyclo-CLLFVY
| M. Wt | 2559.1 |
| Formula | C111H188N42O24S2 |
| Sequence |
CLLFVY CGRKKRRQRRRPPQ* (Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1446322-66-2 |
| PubChem ID | 72192490 |
| InChI Key | AWUUHEHYNQGEFC-XLZVTALKSA-N |
| Smiles | [H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TAT-cyclo-CLLFVY
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for TAT-cyclo-CLLFVY
References for TAT-cyclo-CLLFVY
References are publications that support the biological activity of the product.
Miranda et al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418 PMID: 23796364
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Keywords: TAT-cyclo-CLLFVY, TAT-cyclo-CLLFVY supplier, HIF-1a, 1b, 1beta, 1alpha, α, β, hypoxia, inducible, factor, cancer, angiogenesis, antiangiogenic, dimerization, inhibitors, inhibits, Hypoxia, Inducible, Factors, 5582, Tocris Bioscience
1 Citation for TAT-cyclo-CLLFVY
Citations are publications that use Tocris products. Selected citations for TAT-cyclo-CLLFVY include:
Ying et al (2022) CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy 18 726-744 PMID: 34282994
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