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Submit ReviewWAY 181187 oxalate
Description: High affinity and selective 5-HT6 agonist
Chemical Name: 1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate
Purity: ≥98% (HPLC)
Biological Activity for WAY 181187 oxalate
WAY 181187 oxalate is a high affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc
Compound Libraries for WAY 181187 oxalate
WAY 181187 oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for WAY 181187 oxalate
| M. Wt | 470.91 |
| Formula | C15H13ClN4O2S2.C2H2O4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1883548-85-3 |
| PubChem ID | 121513871 |
| InChI Key | KAFVDFYVWBASDD-UHFFFAOYSA-N |
| Smiles | NCCC2=CN(S(C3=C(Cl)N=C4N3C=CS4)(=O)=O)C1=CC=CC=C12.O=C(O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WAY 181187 oxalate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.09 | 100 |
Preparing Stock Solutions for WAY 181187 oxalate
The following data is based on the product molecular weight 470.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.62 mL | 21.24 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for WAY 181187 oxalate
References for WAY 181187 oxalate
References are publications that support the biological activity of the product.
Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID: 25837696
Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID: 17948978
If you know of a relevant reference for WAY 181187 oxalate, please let us know.
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Keywords: WAY 181187 oxalate, WAY 181187 oxalate supplier, WAY181187, oxalate, 554403-49-5, High, affinity, and, selective, 5-HT6, agonists, activates, sleep, serotonin, receptors, serotonergic, Receptors, 5589, Tocris Bioscience
2 Citations for WAY 181187 oxalate
Citations are publications that use Tocris products. Selected citations for WAY 181187 oxalate include:
David E et al (2022) A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell 185 3390-3407.e18 PMID: 36055200
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
Do you know of a great paper that uses WAY 181187 oxalate from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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