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Submit ReviewSR 7826
Description: Potent and selective LIMK inhibitor; antitumor
Chemical Name: N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea
Purity: ≥98% (HPLC)
Biological Activity for SR 7826
SR 7826 is a potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.
Compound Libraries for SR 7826
SR 7826 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for SR 7826
| M. Wt | 387.43 |
| Formula | C22H21N5O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1219728-20-7 |
| PubChem ID | 45381385 |
| InChI Key | WQAGVQVBDHOHRD-UHFFFAOYSA-N |
| Smiles | O=C(N(CCO)C4=CC=CC=C4)NC(C=C3)=CC=C3C1=C2C(NC=C2C)=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 7826
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.74 | 100 |
Preparing Stock Solutions for SR 7826
The following data is based on the product molecular weight 387.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.91 mL | 25.81 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for SR 7826
References for SR 7826
References are publications that support the biological activity of the product.
Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID: 25621531
If you know of a relevant reference for SR 7826, please let us know.
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Citations for SR 7826
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