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Submit ReviewNFAT inhibitor, Cell Permeable
Description: Cell permeable NFAT inhibitor
Alternative Names: 11R-VIVIT
Purity: ≥95% (HPLC)
Biological Activity for NFAT inhibitor, Cell Permeable
NFAT inhibitor, Cell Permeable is an NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Reduces inflammation and epithelial damage in a mouse model of colitis. In an animal model of Alzheimer's disease NFAT inhibitor improves cognitive and synaptic function, reduces glial activation and lowers amyloid levels; in vitro it reduces glutamate dysregulation and neuron hyperactivity.
Technical Data for NFAT inhibitor, Cell Permeable
| M. Wt | 3573.15 |
| Formula | C147H259N67O36S |
| Sequence | RRRRRRRRRRRGGGMAGPHPVIVITGPHEE |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 592517-80-1 |
| PubChem ID | 16140839 |
| InChI Key | VNTCWMOQGXMIQP-PIQGMSCVSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NFAT inhibitor, Cell Permeable
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for NFAT inhibitor, Cell Permeable
References for NFAT inhibitor, Cell Permeable
References are publications that support the biological activity of the product.
Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID: 22479554
Noguchi et al (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat.Med. 10 305 PMID: 14770176
Lee et al (2022) Function and therapeutic value of astrocytes in neurological diseases. Nat.Rev.Drug Discov. 21 339 PMID: 35173313
Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID: 22479554
Sompol et al (2017) Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice. J.Neurosci. 37 6132 PMID: 28559377
If you know of a relevant reference for NFAT inhibitor, Cell Permeable, please let us know.
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Keywords: NFAT inhibitor, Cell Permeable, NFAT inhibitor, Cell Permeable supplier, NFAT, inhibitors, inhibits, nuclear, factor, of, activated, T, cells, interleukin, IL-12, IL-23, TNF, anti-inflammatory, inflammation, colitis, 11R-VIVIT, amyloid, Alzheimers, glutamate, neurons, immune, suppression, 5710, Tocris Bioscience
Citations for NFAT inhibitor, Cell Permeable
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To determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line.
By
Meghan Bradshaw on 02/20/2019
Species: Human
Cell Line/Tissue: IC-21 cell line
NFAT function in macrophages and we worked to determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line.
