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Submit ReviewPF 06447475
Description: Potent LRRK2 inhibitor; neuroprotective
Chemical Name: 3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile
Purity: ≥98% (HPLC)
Biological Activity for PF 06447475
Potent LRRK2 inhibitor (IC50 = 3 nM). Attenuates α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2 expressing rats. Also neuroprotective in wild type rats. Brain penetrant.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc
Technical Data for PF 06447475
| M. Wt | 305.33 |
| Formula | C17H15N5O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1527473-33-1 |
| PubChem ID | 72706840 |
| InChI Key | BHTWDJBVZQBRKP-UHFFFAOYSA-N |
| Smiles | N#CC1=CC(C3=CNC2=NC=NC(N4CCOCC4)=C23)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 06447475
References for PF 06447475
References are publications that support the biological activity of the product.
Daher et al (2015) Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates α-synuclein gene-induced neurodegeneration. J.Biol.Chem. 290 19433 PMID: 26078453
Henderson et al (2015) Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J.Med.Chem. 58 419 PMID: 25353650
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Keywords: PF 06447475, PF 06447475 supplier, PF06447475, potent, LRRK2, inhibitors, inhibits, neurodegeneration, neuroinflammation, brain, penetrant, 5716, Tocris Bioscience
1 Citation for PF 06447475
Citations are publications that use Tocris products. Selected citations for PF 06447475 include:
Mir et al (2018) The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. Biochem J 475 1861 PMID: 29743203
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Literature in this Area
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.