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Description: Fluorogenic caspase substrate
Chemical Name: N-Acetyl-Leu-Glu-His-Asp-(7-amino-4-trifluoromethylcoumarin)
Biological Activity for Ac-LEHD-AFC
Fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
Technical Data for Ac-LEHD-AFC
| M. Wt | 765.7 |
| Formula | C33H38F3N7O11 |
| Sequence |
LEHD (Modifications: Leu-1 = N-Ac-Leu, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin)) |
| Storage | Desiccate at -20°C |
| CAS Number | 210345-03-2 |
| PubChem ID | 25108576 |
| InChI Key | HULKIXRFKRCRHD-ZJZGAYNASA-N |
| Smiles | CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)NC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ac-LEHD-AFC
References for Ac-LEHD-AFC
References are publications that support the biological activity of the product.
Ito et al (1999) Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. Biochim.Biophys.Acta 1452 263 PMID: 10590315
Moriya et al (2000) Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett. 484 253 PMID: 11078888
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Keywords: Ac-LEHD-AFC, Ac-LEHD-AFC supplier, Fluorogenic, caspases, Proteinases, Proteases, Caspases, 1575, Tocris Bioscience
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