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Description: Potent BRD9/7 inhibitor
Chemical Name: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
Purity: ≥98% (HPLC)
Biological Activity for TP 472
TP 472 is a potent BRD9/7 inhibitor (Kd values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.
Negative Control also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.
Compound Libraries for TP 472
TP 472 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for TP 472
| M. Wt | 333.38 |
| Formula | C20H19N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2079895-62-6 |
| PubChem ID | 123773279 |
| InChI Key | RPBMXJHQYJLPDN-UHFFFAOYSA-N |
| Smiles | O=C(C)C1=CC(C2=CC(C(NC3CC3)=O)=CC=C2C)=C4N=CC=CN41 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TP 472
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.67 | 50 |
Preparing Stock Solutions for TP 472
The following data is based on the product molecular weight 333.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6 mL | 30 mL | 59.99 mL |
| 2.5 mM | 1.2 mL | 6 mL | 12 mL |
| 5 mM | 0.6 mL | 3 mL | 6 mL |
| 25 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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Product Datasheets for TP 472
References for TP 472
References are publications that support the biological activity of the product.
Hohmann and Vakoc et al (2014) A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 30 356 PMID: 24932742
If you know of a relevant reference for TP 472, please let us know.
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Keywords: TP 472, TP 472 supplier, TP472, bromodomains, BRD9, BRD7, inhibitors, potent, CAS, 2079895-62-6, Bromodomains, 6000, Tocris Bioscience
2 Citations for TP 472
Citations are publications that use Tocris products. Selected citations for TP 472 include:
Thomas G et al (2022) The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma. Cells 11 PMID: 35883603
Gatchalian et al (2018) A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun 9 5139 PMID: 30510198
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