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Description: Selective inhibitor of MMP-2
Chemical Name: 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
Purity: ≥99% (HPLC)
Biological Activity for ARP 100
ARP 100 is a selective inhibitor of MMP-2 (IC50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
Technical Data for ARP 100
| M. Wt | 364.42 |
| Formula | C17H20N2O5S |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 704888-90-4 |
| PubChem ID | 10044321 |
| InChI Key | PHGLPDURIUEELR-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)CC(NO)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ARP 100
References for ARP 100
References are publications that support the biological activity of the product.
Rossello et al (2004) New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg.Med.Chem. 12 2441 PMID: 15080939
Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260 PMID: 16483784
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Keywords: ARP 100, ARP 100 supplier, Selective, inhibitors, inhibits, MMP-2, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, ARP100, 2621, Tocris Bioscience
3 Citations for ARP 100
Citations are publications that use Tocris products. Selected citations for ARP 100 include:
Hensley et al (2012) Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia 14 451 PMID: 22787427
Chetty et al (2010) MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Mol Biol Cell 127 1081 PMID: 20027628
Ji et al (2015) WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. Br J Cancer 113 921 PMID: 26291058
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Angiogenesis in Cancer Poster
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