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Submit ReviewCompound W
Discontinued Product
2654 has been discontinued.
Description: γ-secretase inhibitor
Alternative Names: CW
Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid
Purity: ≥99% (HPLC)
Biological Activity for Compound W
Compound W is an inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
Technical Data for Compound W
| M. Wt | 396.31 |
| Formula | C19H12N2O8 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 173550-33-9 |
| PubChem ID | 16760376 |
| InChI Key | JOSXKPZXMVHRKU-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=CC(OC2=CC=C(C=C2)[N+]([O-])=O)=CC(OC2=CC=C(C=C2)[N+]([O-])=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Compound W
References for Compound W
References are publications that support the biological activity of the product.
Okochi et al (2006) Secretion of the notch-1 Aβ-like peptide during notch signaling. J.Biol.Chem. 281 7890 PMID: 16434391
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Keywords: Compound W, Compound W supplier, γ-secretase, gamma-secretase, inhibitors, inhibits, reduces, Aβ4, β42, beta42, levels, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, CompoundW, amyloidbeta, amyloidb, amyloidβ, CW, Gamma-Secretase, Amyloid, Beta, 2654, Tocris Bioscience
2 Citations for Compound W
Citations are publications that use Tocris products. Selected citations for Compound W include:
Ran et al (2015) Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One 10 e0128619 PMID: 26046535
Greife et al (2014) Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer 14 628 PMID: 25167871
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