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Submit ReviewL-364,373
Discontinued Product
2660 has been discontinued.
View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.
Description: KV7.1 channel activator, activates IKs
Alternative Names: R-L3
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
Purity: ≥98% (HPLC)
Biological Activity for L-364,373
L-364,373 is an activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
Technical Data for L-364,373
| M. Wt | 397.44 |
| Formula | C25H20FN3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 103342-82-1 |
| PubChem ID | 656755 |
| InChI Key | CGBANSGENFERAT-JOCHJYFZSA-N |
| Smiles | CN(C1=CC=CC=C1C(C5=CC=CC=C5F)=N[C@@H]2CC3=CNC4=C3C=CC=C4)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-364,373
References for L-364,373
References are publications that support the biological activity of the product.
Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941 PMID: 14576198
Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443 PMID: 16945016
Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220
Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377 PMID: 22251082
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Keywords: L-364,373, L-364,373 supplier, KCNQ1, KVLQT1, kv7.1, channel, activators, activates, IKs, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, L364373, R-L3, Voltage-Gated, 2660, Tocris Bioscience
4 Citations for L-364,373
Citations are publications that use Tocris products. Selected citations for L-364,373 include:
Chadha et al (2014) Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity. Arterioscler Thromb Vasc Biol 34 887 PMID: 24558103
Amarelle et al (2019) Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery. Am J Physiol Lung Cell Mol Physiol 316 L1094 PMID: 30892074
Noblet et al (2015) Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels. Arterioscler Thromb Vasc Biol 35 1393 PMID: 25838427
Chadha et al (2012) Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries. Br J Pharmacol 166 1377 PMID: 22251082
Reviews for L-364,373
Average Rating: 5 (Based on 1 Review.)
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L-364,373 activates IKs in ventricular cells isolated from rats.
By
Eleanor Baxter on 10/23/2018
Assay Type: In Vitro
Species: Rat
L-364,373 activates IKs in ventricular cells isolated from rats. It shows potential as an antiarrhythmic drug.
