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Submit ReviewSodium 4-Phenylbutyrate
Description: Histone deacetylase inhibitor
Alternative Names: 4-PB,Sodium phenylbutyrate
Chemical Name: 4-Phenylbutyric acid, sodium salt
Purity: ≥99% (HPLC)
Biological Activity for Sodium 4-Phenylbutyrate
Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Sodium 4-Phenylbutyrate also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.
Compound Libraries for Sodium 4-Phenylbutyrate
Sodium 4-Phenylbutyrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Sodium 4-Phenylbutyrate
| M. Wt | 186.18 |
| Formula | C10H11NaO2 |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1716-12-7 |
| PubChem ID | 5258 |
| InChI Key | VPZRWNZGLKXFOE-UHFFFAOYSA-M |
| Smiles | [Na+].[O-]C(=O)CCCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sodium 4-Phenylbutyrate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.61 | 100 | |
| DMSO | 4.65 | 25 |
Preparing Stock Solutions for Sodium 4-Phenylbutyrate
The following data is based on the product molecular weight 186.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.37 mL | 26.86 mL | 53.71 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 10 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.07 mL |
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Product Datasheets for Sodium 4-Phenylbutyrate
References for Sodium 4-Phenylbutyrate
References are publications that support the biological activity of the product.
Appelskog et al (2004) Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells. Int.J.Oncol. 24 1419 PMID: 15138583
Ammerpohl et al (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br.J.Cancer 96 73 PMID: 17164759
Engelhard et al (1998) Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J.Neuro-Oncol. 37 97 PMID: 9524087
Khan et al (2011) HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int.J.Mol.Med. 28 977 PMID: 21894430
If you know of a relevant reference for Sodium 4-Phenylbutyrate, please let us know.
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Keywords: Sodium 4-Phenylbutyrate, Sodium 4-Phenylbutyrate supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, 4-PB, Sodium, phenylbutyrate, Non-selective, HDACs, Non-Selective, 2682, Tocris Bioscience
2 Citations for Sodium 4-Phenylbutyrate
Citations are publications that use Tocris products. Selected citations for Sodium 4-Phenylbutyrate include:
Myszor et al (2019) Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity. Sci Rep 9 7114 PMID: 31068616
Karadottir et al (2015) Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells. Oncotarget 3 e1483 PMID: 26664810
Do you know of a great paper that uses Sodium 4-Phenylbutyrate from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.