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Submit ReviewJLK 6
Discontinued Product
2677 has been discontinued.
Description: Inhibitor of γ-secretase-mediated βAPP processing
Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Purity: ≥99% (HPLC)
Biological Activity for JLK 6
JLK 6 is an inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.
Technical Data for JLK 6
| M. Wt | 225.63 |
| Formula | C10H8ClNO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 62252-26-0 |
| PubChem ID | 3803 |
| InChI Key | AMDGKLWVCUXONP-UHFFFAOYSA-N |
| Smiles | COC1=C(Cl)C2=CC=C(N)C=C2C(=O)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JLK 6
References for JLK 6
References are publications that support the biological activity of the product.
Petit et al (2001) New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat.Cell.Biol. 3 507 PMID: 11331880
Petit et al (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J.Neurosci.Res. 74 370 PMID: 14598313
Hellstrom et al (2007) DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445 776 PMID: 17259973
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Citations for JLK 6
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