Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewABS 205
Description: Upregulates NCAM expression. Valproic acid (Cat. No. 2815) derivative
Alternative Names: 4-yn-VPA
Chemical Name: 2-Propyl-4-pentynoic acid
Biological Activity for ABS 205
Orally active valproic acid (Cat No. 2815) derivative that exhibits teratogenic and neuroprotective activity. Upregulates neural cell adhesion molecule (NCAM) expression, activates PPARδ (IC50 = 0.6 mM) and increases Hoxa1 expression in rat embryos. Antiproliferative; induces G1 cell cycle arrest in C6 glioma cells (IC50 ~ 2 mM).
Technical Data for ABS 205
| M. Wt | 140.18 |
| Formula | C8H12O2 |
| Storage | Store at +4°C |
| CAS Number | 24102-11-2 |
| Smiles | CCCC(C(O)=O)CC#C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ABS 205
References for ABS 205
References are publications that support the biological activity of the product.
Bacon et al (1998) Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: application to valproic acid and related analogues of varying potency. Toxicol.In Vitro 12 101 PMID: 20654391
Lampen et al (2005) Modulation of peroxisome proliferator-activated receptor δ activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Mol.Pharmacol. 68 193 PMID: 15829700
Stodgell et al (2006) Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action. Neurotoxicol.Teratol. 28 617 PMID: 16989981
View Related Products by Target
Keywords: ABS 205, ABS 205 supplier, Upregulates, NCAM, expression, Adhesion, Molecules, ABS205, 4-yn-VPA, Cell, 2721, Tocris Bioscience
Citations for ABS 205
Citations are publications that use Tocris products.
Currently there are no citations for ABS 205.
Reviews for ABS 205
There are currently no reviews for this product. Be the first to review ABS 205 and earn rewards!
Have you used ABS 205?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image