Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTCS 401
Description: Selective inhibitor of PTP1B
Chemical Name: 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for TCS 401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
Technical Data for TCS 401
| M. Wt | 306.72 |
| Formula | C10H10N2O5S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 243966-09-8 |
| PubChem ID | 56972185 |
| InChI Key | LQGCAMWQDSYOAY-UHFFFAOYSA-N |
| Smiles | O=C(C(O)=O)NC2=C(C(O)=O)C1=C(S2)CNCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCS 401
References for TCS 401
References are publications that support the biological activity of the product.
Iversen et al (2000) Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem. 275 10300 PMID: 10744717
Andersen et al (2002) Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J.Med.Chem. 45 4443 PMID: 12238924
View Related Products by Target
View Related Products by Product Action
Keywords: TCS 401, TCS 401 supplier, Selective, inhibitors, inhibits, PTP1B, Shp1, Shp2, Protein, Tyrosine, Phosphatases, TCS401, 2754, Tocris Bioscience
1 Citation for TCS 401
Citations are publications that use Tocris products. Selected citations for TCS 401 include:
Du et al (2015) Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. J Neurosci 21 523 PMID: 25999679
Reviews for TCS 401
There are currently no reviews for this product. Be the first to review TCS 401 and earn rewards!
Have you used TCS 401?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image