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Description: Selective GAL2 antagonist
Alternative Names: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide
Purity: ≥95% (HPLC)
Biological Activity for M871
M871 is a selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.
Technical Data for M871
| M. Wt | 2287.64 |
| Formula | C108H163N27O28 |
| Sequence |
WTLNSAGYLLGPEHPPPALALA (Modification: Ala-22 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 908844-75-7 |
| PubChem ID | 90477989 |
| InChI Key | BHKXASDHGWBINL-ZEHYZEGSSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for M871
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for M871
References for M871
References are publications that support the biological activity of the product.
Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273 PMID: 16996122
Sollenburg et al (2006) M871 - a novel peptide antagonist selectively recognizing the galanin receptor type 2. Int.J.Pept.Res.Ther. 12 115
If you know of a relevant reference for M871, please let us know.
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Keywords: M871, M871 supplier, Selective, GAL2, GalR2, antagonists, Receptors, Galanin, Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide, 2698, Tocris Bioscience
6 Citations for M871
Citations are publications that use Tocris products. Selected citations for M871 include:
Fang (2018) Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats. Biochem Pharmacol 156 241 PMID: 30170096
Scanlon et al (2015) Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Int J Neuropsychopharmacol 6 6885 PMID: 25917569
Millón et al (2015) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Immun Inflamm Dis 18 PMID: 25522404
Zhang (2017) Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy Sci Rep 7 45930 PMID: 28378856
Millòn et al (2014) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Int.J.Neuropsychopharmacol. 18 PMID: 25522404
Funck (2018) Dorsal hippocampal galanin modulates anxiety-like behaviours in rats. Brain Res 1688 75 PMID: 29499176
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.