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Submit ReviewBX 513 hydrochloride
Description: Selective CCR1 antagonist
Alternative Names: VUF 2274
Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for BX 513 hydrochloride
BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.
Compound Libraries for BX 513 hydrochloride
BX 513 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for BX 513 hydrochloride
| M. Wt | 481.46 |
| Formula | C28H29ClN2O.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1216540-18-9 |
| PubChem ID | 56972186 |
| InChI Key | SSZWNUGWOGONQJ-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2(O)CCN(CCCC(C4=CC=CC=C4)(C#N)C3=CC=CC=C3)CC2)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BX 513 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.15 | 100 | |
| ethanol | 24.07 | 50 |
Preparing Stock Solutions for BX 513 hydrochloride
The following data is based on the product molecular weight 481.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.39 mL | 20.77 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.15 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for BX 513 hydrochloride
References for BX 513 hydrochloride
References are publications that support the biological activity of the product.
Hesselgesser et al (1998) Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor. J.Biol.Chem. 273 15687 PMID: 9624164
Ng et al (1999) Discovery of a novel non-peptide CCR1 receptor antagonists. J.Med.Chem. 42 4680 PMID: 10579830
Casarosa et al (2003) Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor. J.Biol.Chem. 278 5172 PMID: 12456673
If you know of a relevant reference for BX 513 hydrochloride, please let us know.
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Citations for BX 513 hydrochloride
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