Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGGTI 297
Description: Geranylgeranyltransferase I (GGTase I) inhibitor
Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine trifluoroacetate salt
Purity: ≥95% (HPLC)
Biological Activity for GGTI 297
Geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively). Inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro.
Technical Data for GGTI 297
| M. Wt | 579.63 |
| Formula | C26H31N3O3S.CF3CO2H |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| PubChem ID | 90488779 |
| Smiles | SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](O)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(F)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GGTI 297
References for GGTI 297
References are publications that support the biological activity of the product.
Patel et al (2007) RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J.Pharmacol.Exp.Ther. 32 501 PMID: 17322025
Qian (1998) Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg.Med.Chem. 6 293 PMID: 9568283
View Related Products by Target
View Related Products by Product Action
Keywords: GGTI 297, GGTI 297 supplier, GGTI297, geranylgeranyltransferase-I, GGTase-I, geranyl, inhibitors, inhibits, FTase, RhoA, prenylation, ROCK, Protein, Prenyltransferases, 2774, Tocris Bioscience
Citations for GGTI 297
Citations are publications that use Tocris products.
Currently there are no citations for GGTI 297.
Reviews for GGTI 297
There are currently no reviews for this product. Be the first to review GGTI 297 and earn rewards!
Have you used GGTI 297?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image