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Submit ReviewAG 045572
Discontinued Product
2730 has been discontinued.
View all Gonadotropin-Releasing Hormone Receptors products.
Description: Selective GnRH receptor antagonist
Chemical Name: 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide
Purity: ≥97% (HPLC)
Biological Activity for AG 045572
AG 045572 is a selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.
Technical Data for AG 045572
| M. Wt | 491.62 |
| Formula | C30H37NO5 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 263847-55-8 |
| PubChem ID | 9957278 |
| InChI Key | IPEMCIBPDYCJLO-UHFFFAOYSA-N |
| Smiles | CC(CCC(C)2C)(C)C1=C2C=C(C)C(CC3=CC=C(C(NC4=C(OC)C=C(OC)C=C4OC)=O)O3)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AG 045572
References for AG 045572
References are publications that support the biological activity of the product.
Iatsimirskaia et al (2002) Effect of testost. suppression on the pharmacokinetics of a potent GnRH receptor antagonist. Pharm.Res. 19 202 PMID: 11883648
Anderes et al (2003) Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J.Pharmacol.Exp.Ther. 305 688 PMID: 12606616
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Keywords: AG 045572, AG 045572 supplier, Selective, GnRH, receptor, antagonists, Receptors, Gonadotrophin-Releasing, Hormone, AG045572, gonadotropin, 2730, Tocris Bioscience
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