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Submit ReviewAcetyl-Calpastatin (184-210) (human)
Description: Selective calpain inhibitor
Purity: ≥95% (HPLC)
Biological Activity for Acetyl-Calpastatin (184-210) (human)
Acetyl-Calpastatin (184-210) (human) is a selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
Technical Data for Acetyl-Calpastatin (184-210) (human)
| M. Wt | 3177.65 |
| Formula | C142H230N36O44S |
| Sequence |
DPMSSTYIEELGKREVTIPPKYRELLA (Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 123714-50-1 |
| PubChem ID | 90488788 |
| InChI Key | ZXJCOYBPXOBJMU-HSQGJUDPSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Acetyl-Calpastatin (184-210) (human)
References for Acetyl-Calpastatin (184-210) (human)
References are publications that support the biological activity of the product.
Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866 PMID: 2553724
Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377
Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70
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Keywords: Acetyl-calpastatin 184-210 (human), Acetyl-calpastatin 184-210 (human) supplier, Selective, calpain, inhibitors, inhibits, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Acetyl-calpastatin184-210, (human), Calpains, 2950, Tocris Bioscience
3 Citations for Acetyl-Calpastatin (184-210) (human)
Citations are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:
Davis et al (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. Hypertension 1 e86355 PMID: 27158675
Gerónimo-Olvera et al (2017) Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons. Cell Death Dis 8 e2911 PMID: 28661473
Alvarez-Arce (2017) Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization. Int J Cell Biol 2017 1908310 PMID: 29250115
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Cell Cycle and DNA Damage Research Product Guide
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- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Pathways for Acetyl-Calpastatin (184-210) (human)
