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Description: CRF agonist
Biological Activity for Sauvagine
Sauvagine is a corticotropin-releasing factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b respectively.
Technical Data for Sauvagine
| M. Wt | 4599.35 |
| Formula | C202H346N56O63S |
| Sequence |
XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI (Modifications: X-1 = Glp, Ile-40 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 74434-59-6 |
| PubChem ID | 16132335 |
| InChI Key | ILCVKEBXPLEGOY-ZLFMSJRASA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Sauvagine
References for Sauvagine
References are publications that support the biological activity of the product.
Eckart et al (1999) Actions of CRF and its analogues. Curr.Med.Chem. 6 1035 PMID: 10519912
Montecucchi and Henschen (1981) Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of PHYLLOMEDUSA SAWAGEI. Int.J.Pept.Protein Res. 18 113 PMID: 7309372
Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663
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Keywords: Sauvagine, Sauvagine supplier, CRF, agonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Non-selective, 1609, Tocris Bioscience
Citations for Sauvagine
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Currently there are no citations for Sauvagine.
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.