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Submit ReviewArachidonyl serotonin
Description: Dual FAAH inhibitor/TRPV1 antagonist
Alternative Names: AA-5-HT
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
Biological Activity for Arachidonyl serotonin
Arachidonyl serotonin is a dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
Technical Data for Arachidonyl serotonin
| M. Wt | 462.67 |
| Formula | C30H42N2O2 |
| Storage | Store at -20°C |
| CAS Number | 187947-37-1 |
| PubChem ID | 10027372 |
| InChI Key | QJDNHGXNNRLIGA-DOFZRALJSA-N |
| Smiles | O=C(NCCC1=CNC2=C1C=C(O)C=C2)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Arachidonyl serotonin
References for Arachidonyl serotonin
References are publications that support the biological activity of the product.
Di Marzo et al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771 PMID: 15340387
Maione et al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766 PMID: 17279090
Bisogno et al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248 515
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Keywords: Arachidonyl serotonin, Arachidonyl serotonin supplier, Dual, FAAH, inhibitors, inhibits, TRPV1, antagonists, cannabinoids, Receptors, Vanillioid, VR1, Channels, Transient, Receptor, Potential, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AA5HT, AA-5-HT, Other, Cannabinoids, TRPV, Hydrolase, (FAAH), 2836, Tocris Bioscience
Citations for Arachidonyl serotonin
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Literature in this Area
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.