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Submit ReviewCP 80633
Description: Selective PDE4 inhibitor
Chemical Name: 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone
Purity: ≥99% (HPLC)
Biological Activity for CP 80633
CP 80633 is a selective inhibitor of phosphodiesterase type 4 (IC50 values are 1.9, > 100, > 100, > 100 and > 100 μM for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells. Displays anti-inflammatory and bronchodilatory effects in vivo.
Technical Data for CP 80633
| M. Wt | 316.39 |
| Formula | C18H24N2O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 135637-46-6 |
| PubChem ID | 9861730 |
| InChI Key | LITNEAPWQHVPOK-FFSVYQOJSA-N |
| Smiles | O=C(NC4)NCC4C1=CC(O[C@H]2C[C@@H]3CC[C@H]2C3)=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CP 80633
References for CP 80633
References are publications that support the biological activity of the product.
Turner et al (1996) The in vivo pharmacology of CP-80,633, a selective inhibitor of phosphodiesterase 4. J.Pharmacol.Exp.Ther. 278 1349 PMID: 8819522
Cohan et al (1996) In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633. J.Pharmacol.Exp.Ther. 278 1356 PMID: 8819523
Cheng et al (1997) The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice: effect of adrenalectomy. J.Pharmacol.Exp.Ther. 280 621 PMID: 9023272
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Keywords: CP 80633, CP 80633 supplier, Selective, PDE4, inhibitors, inhibits, Phosphodiesterases, CP80633, 2729, Tocris Bioscience
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