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Submit ReviewU 93631
Description: GABAA antagonist
Chemical Name: 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester
Purity: ≥99% (HPLC)
Biological Activity for U 93631
U 93631 is a GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.
Technical Data for U 93631
| M. Wt | 299.37 |
| Formula | C17H21N3O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 152273-12-6 |
| PubChem ID | 197626 |
| InChI Key | NXBSEJKZKXIYMD-UHFFFAOYSA-N |
| Smiles | CC(C)(C)OC(=O)C1=C2N(C=N1)C1=CC=CC=C1NC2(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for U 93631
References for U 93631
References are publications that support the biological activity of the product.
Dillon et al (1993) U-93631 causes rapid decay of γ-aminobutyric acid-induced chloride currents in recombinant rat γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 860 PMID: 8232235
Dillon et al (1995) [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J.Pharmacol.Exp.Ther. 272 597 PMID: 7531762
Das et al (2003) The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors. Neuropharmacology 44 431 PMID: 12646280
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Keywords: U 93631, U 93631 supplier, GABAA, receptor, antagonists, Receptors, U93631, 2745, Tocris Bioscience
Citations for U 93631
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Literature in this Area
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