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SecinH3

Cat. No. 2849 4 Citations Submit a Review Datasheet / COA / SDS
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Description: Sec7-specific GEF inhibitor; selective for cytohesin family
Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SecinH3

SecinH3 is a Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

Compound Libraries for SecinH3

SecinH3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SecinH3

M. Wt 460.5
Formula C24H20N4O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 853625-60-2
PubChem ID 1029232
InChI Key QPGYAMIHXLCFTJ-UHFFFAOYSA-N
Smiles O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SecinH3

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.05 100

Preparing Stock Solutions for SecinH3

The following data is based on the product molecular weight 460.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.72 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

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Product Datasheets for SecinH3

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for SecinH3

References are publications that support the biological activity of the product.

Hafner et al (2006) Inhibition of cytohesins by secinH3 leads to hepatic Ins resistance. Nature 444 941 PMID: 17167487

Fuss et al (2006) The cytohesin Steppke is essential for Ins signalling in Drosophila. Nature 444 945 PMID: 17167488

If you know of a relevant reference for SecinH3, please let us know.

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Keywords: SecinH3, SecinH3 supplier, Sec7-specific, GEF, inhibitors, inhibits, cytohesins, hCyh2, hCyh1, mCyh3, hCyh3, drosophila, steppke, G, Proteins, Small, Arf, 2849, Tocris Bioscience

4 Citations for SecinH3

Citations are publications that use Tocris products. Selected citations for SecinH3 include:

Risse et al (2011) Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Pain 300 L958 PMID: 21460123

Ford et al (2018) Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog 14 e1007051 PMID: 29727463

Abdul-Salam et al (2019) CLIC4/Arf6 Pathway. Circ Res 124 52 PMID: 30582444

Guichard et al (2017) Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog 13 e1006603 PMID: 28945820

Do you know of a great paper that uses SecinH3 from Tocris? Please let us know.

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