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Description: D4 and 5-HT2A antagonist; antipsychotic
Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for PNU 96415E
PNU 96415E is an antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.
Technical Data for PNU 96415E
| M. Wt | 413.36 |
| Formula | C21H25FN2O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 170856-41-4 |
| PubChem ID | 9909647 |
| InChI Key | OGMGYKPECFQXJJ-UHFFFAOYSA-N |
| Smiles | FC(C=C4)=CC=C4N(CC3)CCN3CCC2C1=CC=CC=C1CCO2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PNU 96415E
References for PNU 96415E
References are publications that support the biological activity of the product.
Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440 PMID: 9103528
Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic cloz. in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699 PMID: 9890260
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Keywords: PNU 96415E, PNU 96415E supplier, 5-HT2A, D4, antagonists, antipsychotic, Serotonin, Receptors, Dopamine, dopaminergic, PNU96415E, 2735, Tocris Bioscience
1 Citation for PNU 96415E
Citations are publications that use Tocris products. Selected citations for PNU 96415E include:
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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