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Description: Ornithine decarboxylase inhibitor
Alternative Names: Eflornithine
Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride
Biological Activity for DFMO
DFMO is an irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.
Technical Data for DFMO
| M. Wt | 218.63 |
| Formula | C6H12F2N2O2.HCl |
| Storage | Desiccate at RT |
| CAS Number | 68278-23-9 |
| PubChem ID | 57004 |
| InChI Key | VKDGNNYJFSHYKD-UHFFFAOYSA-N |
| Smiles | NC(C(F)F)(C(O)=O)CCCN.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DFMO
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.4 | 75 |
Preparing Stock Solutions for DFMO
The following data is based on the product molecular weight 218.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 6.1 mL | 30.49 mL | 60.99 mL |
| 3.75 mM | 1.22 mL | 6.1 mL | 12.2 mL |
| 7.5 mM | 0.61 mL | 3.05 mL | 6.1 mL |
| 37.5 mM | 0.12 mL | 0.61 mL | 1.22 mL |
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Product Datasheets for DFMO
References for DFMO
References are publications that support the biological activity of the product.
Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353 PMID: 17371277
Carrillo et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279 663
Wu et al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693 PMID: 22132744
If you know of a relevant reference for DFMO, please let us know.
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Keywords: DFMO, DFMO supplier, Ornithine, decarboxylases, inhibitors, inhibits, Eflornithine, Decarboxylases, 2761, Tocris Bioscience
1 Citation for DFMO
Citations are publications that use Tocris products. Selected citations for DFMO include:
Machado et al (2021) Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell 28 1 PMID: 33609440
Do you know of a great paper that uses DFMO from Tocris? Please let us know.
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