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Description: Promotes inclusion formation in Huntington's and Parkinson's diseases
Alternative Names: CPNQ
Chemical Name: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
Purity: ≥98% (HPLC)
Biological Activity for B2
B2 is a promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
Technical Data for B2
| M. Wt | 396.83 |
| Formula | C20H17ClN4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 115687-05-3 |
| PubChem ID | 3953303 |
| InChI Key | KLNPVNZJCWIQSK-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(Cl)C=C4)N(CC3)CCN3C1=C(C=CC=N2)C2=C([N+]([O-])=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for B2
References for B2
References are publications that support the biological activity of the product.
Bodner et al (2006) Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parksinson's diseases. Proc.Natl.Acad.Sci.USA 103 4246
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Keywords: B2, B2 supplier, Promotes, inclusion, formation, Huntingtons, Parkinsons, parkinson's, diseases, Huntingdons, Neuronal, Metabolism, Huntington's, CPNQ, Miscellaneous, Compounds, 2855, Tocris Bioscience
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