NBMPR

Cat. No. 2924 5 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Equilibrative nucleoside transporter 1 (ENT1) inhibitor

Chemical Name: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine

Purity: ≥99% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NBMPR

NBMPR is an equilibrative nucleoside transporter 1 (ENT1) inhibitor (K_i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Compound Libraries for NBMPR

NBMPR is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NBMPR

M. Wt	419.41
Formula	C₁₇H₁₇N₅O₆S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	38048-32-7
PubChem ID	65407
InChI Key	DYCJFJRCWPVDHY-LSCFUAHRSA-N
Smiles	OC[C@H]1O[C@@H](N2C=NC3=C2N=CN=C3SCC4=CC=C([N+]([O-])=O)C=C4)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NBMPR

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.94	100

Preparing Stock Solutions for NBMPR

The following data is based on the product molecular weight 419.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Product Datasheets for NBMPR

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for NBMPR

References are publications that support the biological activity of the product.

Ward et al (2000) Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 275 8375 PMID: 10722669

Tsujie et al (2007) Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 27 2241 PMID: 17695509

Lin and Buolamwini (2007) Synthesis and flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949

If you know of a relevant reference for NBMPR, please let us know.

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