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Submit ReviewCRF (6-33)
Description: CRF-binding protein inhibitor
Alternative Names: Corticotropin-Releasing Factor (6-33)
Biological Activity for CRF (6-33)
CRF (6-33) is a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.
Licensing Information
Sold with the permission of the SALK Institute
Technical Data for CRF (6-33)
| M. Wt | 3220.68 |
| Formula | C141H231N41O43S |
| Sequence | ISLDLTFHLLREVLEMARAEQLAQQAHS |
| Storage | Desiccate at -20°C |
| CAS Number | 120066-38-8 |
| PubChem ID | 16135485 |
| InChI Key | XHHPINGDTRCKNN-QZXFXOMNSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CRF (6-33)
References for CRF (6-33)
References are publications that support the biological activity of the product.
Heinrichs et al (2001) Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav.Brain Res. 122 43 PMID: 11287075
Heinrichs et al (2001) Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol.Behav. 74 5 PMID: 11564446
Jahn et al (2002) The binding protein of corticotropin-releasing factor: ligand-binding site and subunit structure. Proc.Natl.Acad.Sci.U.S.A. 99 12055 PMID: 12215497
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Keywords: CRF (6-33), CRF (6-33) supplier, CRF-binding, protein, inhibitors, inhibits, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Corticotropin, Releasing, (6-33), Non-selective, CRF, 1607, Tocris Bioscience
Citations for CRF (6-33)
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Currently there are no citations for CRF (6-33).
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.