Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMMPIP hydrochloride
Discontinued Product
2963 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Potent and selective negative allosteric modulator of mGlu7 receptors
Chemical Name: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for MMPIP hydrochloride
MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.
Technical Data for MMPIP hydrochloride
| M. Wt | 369.8 |
| Formula | C19H15N3O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1215566-78-1 |
| PubChem ID | 52974245 |
| InChI Key | HXHQNERSIJXMTQ-UHFFFAOYSA-N |
| Smiles | O=C1N(C)C(C3=CC=C(OC)C=C3)=CC2=C1C(C4=CC=NC=C4)=NO2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MMPIP hydrochloride
References for MMPIP hydrochloride
References are publications that support the biological activity of the product.
Suzuki et al (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 323 147 PMID: 17609420
View Related Products by Target
View Related Products by Product Action
View all Glutamate (Metabotropic) Group III Receptor Modulators
Keywords: MMPIP hydrochloride, MMPIP hydrochloride supplier, Potent, allosteric, mGlu7, mGluR7-selective, antagonists, Group, III, Receptors, Glutamate, Metabotropic, NAM, (Metabotropic), 2963, Tocris Bioscience
4 Citations for MMPIP hydrochloride
Citations are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:
Jantas et al (2018) New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology 141 223 PMID: 30170084
Kammermeier (2015) Constitutive activity of metabotropic glutamate receptor 7. Front Pediatr 16 17 PMID: 25881041
Johansson et al (2015) Activation of a temporal memory in purkinje cells by the mGluR7 receptor. Cell Rep. 13 1741 PMID: 26655894
Palazzo et al (2013) Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat. Mol Pain 9 44 PMID: 24004843
Reviews for MMPIP hydrochloride
There are currently no reviews for this product. Be the first to review MMPIP hydrochloride and earn rewards!
Have you used MMPIP hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.