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Calcipotriol

Cat. No. 2700 3 Citations 1 Review Submit a Review Datasheet / COA / SDS
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Description: Vitamin D3 analog
Alternative Names: MC 903
Chemical Name: (1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Calcipotriol

Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.

Technical Data for Calcipotriol

M. Wt 412.6
Formula C27H40O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 112965-21-6
PubChem ID 5288783
InChI Key LWQQLNNNIPYSNX-UROSTWAQSA-N
Smiles [H][C@@]12[C@]([C@]([C@@H](/C=C/[C@@H](O)C4CC4)C)([H])CC2)(C)CCC/C1=C\C=C3/C([C@@H](O)C[C@H](O)C3)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Calcipotriol

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.26 100
ethanol 41.26 100

Preparing Stock Solutions for Calcipotriol

The following data is based on the product molecular weight 412.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for Calcipotriol

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Calcipotriol

References are publications that support the biological activity of the product.

Binderu (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240 PMID: 8396769

Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829 PMID: 9113104

Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447 PMID: 17351397

Lovato et al (2016) Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J.Dermatol.Sci. 81 153 PMID: 26794805

Cunningham et al (2017) Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J.Clin.Invest. 127 106 PMID: 27869649

If you know of a relevant reference for Calcipotriol, please let us know.

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Keywords: Calcipotriol, Calcipotriol supplier, Vitamin, D3, D, Receptors, VDR-like, MC903, analogues, MC, 903, 2700, Tocris Bioscience

3 Citations for Calcipotriol

Citations are publications that use Tocris products. Selected citations for Calcipotriol include:

Landheer et al (2015) TSLP is differentially regulated by vitamin D3 and cytokines in human skin. Dev.Biol. 3 32 PMID: 25866638

Malhotra et al (2018) RORα-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol 3 PMID: 29500225

Wei et al (2018) Vitamin D switches BAF complexes to protect β cells. Cell 173 1135 PMID: 29754817

Do you know of a great paper that uses Calcipotriol from Tocris? Please let us know.

Reviews for Calcipotriol

Average Rating: 5 (Based on 1 Review.)

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MC903 treatment and pathology assessment.
By Jing Feng on 01/10/2018
Assay Type: In Vivo
Species: Mouse

MC903 was used to induce an Atopical Dermatitis-like inflammation and itch

review image